One of the important aspects of the medicinal plants production is using less chemical inputs. It could be effective for increasing of production and environmental purposes. In order to investigate the effects of application time of integrated chemical fertilizer with cattle manure on growth, yield and yield components of black cumin (Nigella sativa L.), an experiment was conducted based on a randomized complete block design with nine treatments and three replications in Research Farm of Shahrekord University during growing season 2011-2012. The treatments consisted of control (no amended nitrogen), cattle manure, urea, three levels of split integrated fertilizers such as cattle manure + urea, cattle manure + cattle manure + urea, and three levels of full integrated fertilizers including cattle manure + urea, cattle manure + cattle manure + urea. The results indicated that integrated application of cattle manure with chemical fertilizer caused significant increase in number of main branch per plant (%11.5), number of capsules per plant (%9.5), 1000-seed weight (%7.4), capsule weight (%5.9), biological yield (%36.7) of black cumin. Full dose application of urea fertilizer with cattle manure (50:50) due to improve of capsules per plant and 1000-seed weight increased significantly grain yield (2397 kg.ha-1). In general, use of integrated cattle manure with chemical fertilizer, full dose application of urea specially, with increasing of fertilizer efficiency led to improve of quantitative characteristic in black cumin. This method caused to cost eliminate of top dressing fertilizer and it can be effective for environment and medicinal plant health.